Andrew E Aplin Selected Research

Polo-Like Kinase 1

1/2019

In Vivo ERK1/2 Reporter Predictively Models Response and Resistance to Combined BRAF and MEK Inhibitors in Melanoma.

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Andrew E Aplin Research Topics

Disease

69	Melanoma (Melanoma, Malignant) 11/2022 - 09/2003
55	Neoplasms (Cancer) 11/2022 - 04/2005
17	Uveal melanoma 01/2022 - 07/2015
9	Neoplasm Metastasis (Metastasis) 01/2021 - 09/2015
5	Breast Neoplasms (Breast Cancer) 01/2020 - 10/2006
3	Disease Progression 01/2020 - 01/2012
2	Carcinogenesis 01/2019 - 10/2006
1	Neurofibrosarcoma (MPNST) 01/2021
1	Eye Neoplasms (Eye Cancer) 01/2021
1	Weight Loss (Weight Reduction) 01/2020
1	Autosomal Dominant 5 Deafness 11/2019
1	Virus Diseases (Viral Diseases) 10/2019
1	Infections 10/2019

Drug/Important Bio-Agent (IBA)

37	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2022 - 05/2005
19	Proteins (Proteins, Gene)FDA Link 01/2022 - 04/2009
12	VemurafenibIBA 01/2018 - 09/2011
10	Pharmaceutical PreparationsIBA 11/2022 - 10/2006
7	Transcription Factors (Transcription Factor)IBA 01/2022 - 01/2011
7	Immune Checkpoint InhibitorsIBA 01/2022 - 11/2017
6	PLX 4720IBA 06/2017 - 08/2010
5	Phosphotransferases (Kinase)IBA 11/2022 - 12/2011
5	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 01/2021 - 03/2009
5	PLX51107IBA 01/2020 - 01/2019
4	Neuregulin-1 (Neuregulin 1)IBA 10/2018 - 08/2014
4	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 12/2012 - 05/2005
4	Small Interfering RNA (siRNA)IBA 12/2010 - 02/2008
3	RNA (Ribonucleic Acid)IBA 01/2022 - 01/2019
3	AntibodiesIBA 01/2022 - 08/2014
3	GTP-Binding Proteins (G-Protein)IBA 11/2021 - 01/2018
3	Biological ProductsIBA 01/2021 - 01/2017
3	Mitogen-Activated Protein Kinase 3IBA 11/2020 - 04/2009
3	Cyclin-Dependent Kinases (cdk Proteins)IBA 01/2020 - 01/2016
3	Estrogen ReceptorsIBA 01/2020 - 01/2016
3	Messenger RNA (mRNA)IBA 01/2019 - 10/2010
3	Protein Isoforms (Isoforms)IBA 11/2018 - 09/2015
3	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 10/2018 - 05/2005
3	trametinibIBA 01/2017 - 07/2015
3	Fibronectins (Fibronectin)IBA 09/2015 - 09/2006
3	dabrafenibIBA 05/2014 - 12/2013
3	IntegrinsIBA 10/2010 - 09/2003
3	Cyclin D1IBA 04/2010 - 05/2005
2	Cadherins (E-Cadherin)IBA 01/2022 - 09/2015
2	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2021 - 01/2017
2	Drug CombinationsIBA 01/2020 - 01/2018
2	tyrosine receptor (receptor, tyrosine)IBA 01/2020 - 12/2011
2	MitogensIBA 02/2016 - 04/2010
2	LigandsIBA 09/2015 - 12/2011
2	Monoclonal AntibodiesIBA 07/2015 - 08/2014
2	GTP Phosphohydrolases (GTPases)IBA 10/2014 - 03/2009
2	CyclinsIBA 11/2008 - 09/2006
1	Acetylcysteine (Siran)FDA LinkGeneric 01/2022
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2022
1	Syndecan-2IBA 01/2022
1	Adenosine Monophosphate (AMP)IBA 01/2022
1	Cell Adhesion Molecule-1IBA 01/2022
1	Pyruvic Acid (Pyruvate)IBA 01/2022
1	Oxidoreductases (Dehydrogenase)IBA 01/2022
1	Cell Adhesion MoleculesIBA 01/2022
1	Pyruvate Dehydrogenase Acetyl-Transferring KinaseIBA 01/2022
1	Immune Checkpoint ProteinsIBA 12/2021
1	CEACAM1 ProteinIBA 12/2021
1	mirdametinibIBA 11/2020
1	Glutathione (Reduced Glutathione)IBA 11/2020
1	pexidartinibIBA 01/2020
1	IACS-010759IBA 01/2020
1	Decitabine FDA Link 01/2020
1	HMGB1 Protein (HMG1)IBA 01/2020
1	Aromatase InhibitorsIBA 01/2020
1	4-1BB Ligand (4 1BB Ligand)IBA 01/2020
1	Caspase 3 (Caspase-3)IBA 11/2019
1	Guanine Nucleotide Dissociation Inhibitors (GDIs)IBA 11/2019
1	Clodronic Acid (Clodronate)IBA 10/2019
1	ChemokinesIBA 10/2019
1	VaccinesIBA 10/2019
1	Alpha-Ketoglutarate-Dependent Dioxygenase FTOIBA 01/2019
1	FR900359IBA 01/2019
1	6-methyladenineIBA 01/2019
1	N-methyladenosineIBA 01/2019
1	Polo-Like Kinase 1IBA 01/2019
1	human ERBB2 proteinIBA 01/2019
1	Biomarkers (Surrogate Marker)IBA 01/2019
1	AZD4547IBA 01/2019
1	Interferon-gamma (Interferon, gamma)IBA 01/2019
1	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA 01/2019
1	vistusertibIBA 01/2018
1	COUP Transcription Factor IIBA 01/2018
1	PLX8394IBA 01/2018
1	Mechanistic Target of Rapamycin Complex 1IBA 01/2018
1	Transforming Growth Factor beta (TGF-beta)IBA 01/2018
1	Rosiglitazone (Avandia)FDA Link 06/2017
1	ThiazolidinedionesIBA 06/2017
1	merestinibIBA 01/2017
1	Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA 01/2017

Therapy/Procedure

41	Therapeutics 11/2022 - 01/2011
4	Immunotherapy 11/2022 - 01/2018
3	Precision Medicine 11/2022 - 01/2012
3	Salvage Therapy 01/2020 - 01/2018
1	Neoadjuvant Therapy 11/2022
1	Splenectomy 01/2020
1	Injections 10/2019